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Biodegradable Collagen Matrix

Ologen box

Device description

  • Type I atelocollagen with a 3D porous structure and pore diameter between 10-300µm

  • Comprises > 90% atelocollagen and < 10% glycosaminoglycan (GAG)

  • Dry form scaffold

  • Biodegraded in approximately 3 to 6 months

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Surgery & Mechanism

Ologen™ Collagen Matrix helps to control scar formation.

Myofibroblasts_1

Myofibroblasts that are involved in the remodelling phase of wound healing migrate into the ologen™ CM scaffold, settle and adhere. 

Myofibroblasts_2

While a new collagen matrix is being produced by the Myofibroblasts, the ologen™ CM  starts to degrade.

Myofibroblasts_3

ologen™ CM degradation process continues and the scaffold is replaced by myofibroblast produced matrix.

Combination of XEN + MMC and ologen™ Collagen Matrix - IOL injector technique

Schematic representation of the surgical technique
Early bleb fibrosis

ologen™ CM present

Early bleb fibrosis (<1 month)

7.7%*

to

4.3%**

Late bleb fibrosis

ologen™ CM present

Late bleb fibrosis (1 month - 1 year)

46%*

to

4.3%**

at 12 months

Needling procedures

ologen™ CM present

Needling procedures

23.1%*

to

13%**

at 12 months

*n=39 (eye evaluated at 12 months) 1 **n=23 (eye evaluated at 12 months)1

References:
1. Rodríguez, José MN, et al. "Efficacy of the Ologen® collagen matrix in combination with the XEN® gel stent implantation in the treatment of openangle glaucoma: a case‐control study." Clinical & Experimental Ophthalmology (2020).

The use of ologen™ Collagen Matrix in combination with XEN implant results in a significant reduction of IOP and number of medications, as well as a better control of conjunctival fibrosis, less need for postoperative interventions with no significant added risk.
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Welcome to ProSys International Limited. We design, manufacture and market a wide range of UKCA and CE marked Medical Devices for a multitude of clinical specialities & applications. We are the exclusive UK & Ireland distributor for one of Europe’s leading manufacturers of medical devices, Dahlhausen.

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